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Adrian M Senderowicz Selected Research

Cyclin-Dependent Kinases (cdk Proteins)

1/2005Inhibitors of cyclin-dependent kinase modulators for cancer therapy.
5/2004UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.
11/2003Cell cycle modulators for the treatment of lung malignancies.
7/2003Novel small molecule cyclin-dependent kinases modulators in human clinical trials.
7/2003Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
4/2003Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.
11/2002Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).
10/2002Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
3/2002Perifosine, a novel alkylphospholipid, induces p21(WAF1) expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
1/2002Cyclin-dependent kinases as targets for cancer therapy.
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Adrian M Senderowicz Research Topics

Disease

24Neoplasms (Cancer)
11/2014 - 01/2002
5Carcinogenesis
06/2009 - 07/2003
4Retinoblastoma (Glioblastoma, Retinal)
11/2003 - 01/2002
3Diarrhea
11/2014 - 02/2003
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2008 - 03/2002
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2008 - 12/2007
2Carcinoma (Carcinomatosis)
04/2005 - 11/2002
2Nausea
09/2003 - 07/2003
2Hypoxia (Hypoxemia)
09/2003 - 07/2003
2Vomiting
09/2003 - 07/2003
2Hyperglycemia
09/2003 - 07/2003
1Thymus Hyperplasia
06/2009
1Hyperplasia
08/2008
1Adenocarcinoma
12/2007
1Pancreatic Neoplasms (Pancreatic Cancer)
12/2007
1Prostatic Neoplasms (Prostate Cancer)
04/2005
1Lung Neoplasms (Lung Cancer)
09/2003
1Pain (Aches)
02/2003
1Fever (Fevers)
02/2003
1Fatigue
02/2003
1Squamous Cell Carcinoma of Head and Neck
11/2002
1Breast Neoplasms (Breast Cancer)
01/2002

Drug/Important Bio-Agent (IBA)

12Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2005 - 01/2002
6alvocidib (flavopiridol)IBA
10/2003 - 01/2002
47-hydroxystaurosporine (UCN 01)IBA
10/2004 - 01/2002
3Pharmaceutical PreparationsIBA
11/2014 - 11/2002
3Cyclin D1IBA
06/2009 - 05/2002
2perifosineIBA
11/2014 - 03/2002
2CyclinsIBA
06/2009 - 08/2003
2GemcitabineFDA Link
12/2007 - 09/2003
2Insulin (Novolin)FDA Link
09/2003 - 07/2003
1OF 900IBA
11/2014
1Keratin-5 (Keratin 5)IBA
08/2008
1Phosphotransferases (Kinase)IBA
08/2008
1phorbolIBA
02/2008
1Erlotinib Hydrochloride (CP 358,774)FDA Link
12/2007
1Tyrosine Kinase InhibitorsIBA
12/2007
1ErbB Receptors (EGF Receptor)IBA
12/2007
1IsoflavonesIBA
04/2005
1phenoxodiolIBA
04/2005
1GenisteinIBA
04/2005
1Proliferating Cell Nuclear Antigen (PCNA)IBA
04/2005
1Taxoids (Taxanes)IBA
09/2003
1Gefitinib (Iressa)FDA Link
09/2003
1PlatinumIBA
09/2003
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
08/2003
1adducinIBA
07/2003
1Proteins (Proteins, Gene)FDA Link
02/2003
1Acute-Phase Proteins (Acute-Phase Protein)IBA
02/2003
1Protein Kinase CIBA
11/2002
1Cyclin-Dependent Kinase Inhibitor p27IBA
11/2002
1Cyclin D3IBA
11/2002
1DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
11/2002
1Biomarkers (Surrogate Marker)IBA
11/2002
1Adenosine Triphosphate (ATP)IBA
10/2002
1Antineoplastic Agents (Antineoplastics)IBA
03/2002
1Complementary DNA (cDNA)IBA
01/2002

Therapy/Procedure

10Therapeutics
03/2010 - 01/2002
3Drug Therapy (Chemotherapy)
12/2007 - 09/2003
1Chemoprevention
03/2010